Research Articles

2020  |  Vol: 6(4)  |  Issue: 4 (July- August)  |  https://doi.org/10.31024/ajpp.2020.6.4.1
Design, characterization and evaluation of hydrogel based Timolol formulation for effective treatment of Glaucoma

Deepesh Lall*

Department of Pharmaceutics, LCIT School of pharmacy, Bilaspur, Chhattisgarh, India

*Address for corresponding Author

Deepesh lall

Department of Pharmaceutics, LCIT School of pharmacy, Bilaspur, Chhattisgarh, India

 

Abstract

Objective: An attempt has been made with the three dimensional structured hydrogel based formulation. Objective of the work to design, development and characterization of Timolol hydrogel formulation for Glaucoma with minimum dose of timolol about 0.1% achieved maximum therapeutics response with prolonged duration of application. Materials and methods:  Material were used in this research work the raw drug of Timolol maleate, gellun gum, chitosan, PLGA and other materials of analytical grade used. Cold condensation method was used to prepare timolol hydrogel. Prepared hydrogel was characterized by different parameters like release pattern, viscosity, pH, permeation and sterility. Results and conclusion: Results were showed timolol maleate under hydrogel formulation possess much stable and increase in bioavailability with compare to its convectional dosage form. It was showed that hydrogel enhances the contact time into the eye after administering with prolonged duration of drug release from the formulation without possess any inflammation and side effects. Timolol maleate under hydrogel formulation comes with various advantageous over present formulation, it requires less dosage 0.1% of Timolol maleate in single administration, among present formulation in the marketed this attempt hydrogel formulation would be definitely beneficial with appropriate less dose uses with maximum therapeutic responses. Much stable with prolonged duration drug release can be achieved.

Keywords: Bioavailability, timolol maleate, hydrogel, glaucoma, cold condensation

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