Research Articles

2022  |  Vol: 8(5)  |  Issue: 5(September-October)  |  https://doi.org/10.31024/ajpp.2022.8.5.1
Effect of aqueous extract of Citrullus lanatus Rind on ethanol-induced hepatotoxicity in rats

R. Aishwarya, Hema Kumari, R. Padmavathi*

Department of Pharmacology, G. Pulla Reddy College of Pharmacy, Hyderabad, Telangana, India

*Address for Corresponding Author

Dr R. Padmavathi

Associate professor,

Department of Pharmacology,

G. Pulla Reddy College of Pharmacy, Hyderabad – 500028, Telangana, India

 

Abstract

Objective: The present study was conducted to investigate that aqueous extract of Citrullus lanatus rind (CLRE) would ameliorate the hepatic damage caused by Ethanol. Materials and Methods: Thirty male wistar rats were divided into 5 groups as follows, Group-1 served as Control group, Group-2 as Disease control (20 ml/kg of 40% Ethanol on 28th day) and Groups-3, 4, 5 served as treatment groups 100 mg/kg, 200 mg/kg, 400 mg/kg of CLRE for 27 days and on 28th day 20 ml/kg of 40% Ethanol respectively. The hepatoprotective activity was evaluated by determining the liver serum parameters i.e., alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), anti-oxidant parameters like superoxide dismutase (SOD) and catalase (CAT), oxidative stress parameters - Malondialdehyde (MDA) and histopathological examinations. Results: Ethanol toxicity led to significant increase (P<0.001) of serum levels of AST, ALT, ALP and increased levels of MDA and decreased levels of SOD, catalase with multiple histological damage. Interestingly, Pre-treatment with CLRE, dose-dependently and significantly attenuated the changes caused by Ethanol administration. Conclusion: This study reveals that CLRE possesses hepatoprotective activity against 40% ethanol in dose dependent manner in rats.

Keywords: Citrullus lanatus rind, hepatotoxicity, ethanol, hepatoprotective, malondialdehyde

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