Research Articles

2019  |  Vol: 5(2)  |  Issue: 2(March-April)  |  https://doi.org/10.31024/ajpp.2019.5.2.21
Synthesis, characterization and antimicrobial evaluation of novel azole based (Benzoic Acid) derivatives

Birendra Shrivastava1*, Omprakash Sharma2, Pankaj Sharma3, Jitender Singh4

1Director, School of Pharmaceutical Sciences, Jaipur National University, Jaipur, Rajasthan, India, 302025

2Research Scholar, School of Pharmaceutical Sciences, Jaipur National University, Jaipur, Rajasthan, India, 302025

3Professor, School of Pharmaceutical Sciences, Jaipur National University, Jaipur, Rajasthan, India, 302025

4Professor, Lord Shiva College of Pharmacy, Sirsa, Haryana, 125055 India

*Address for Corresponding Author

Prof. Birendra Shrivastava

Director, School of Pharmaceutical Sciences, Jaipur National University, Jaipur, Rajasthan, 302025, India

Abstract

Objective: The aim of present study was the Synthesis and characterization of Azoles Based Benzoic Acid Derivative. Materials and Methods: The compounds were prepared by reaction of Benzoic Acid with thiosemicarbazide in the presence of Phosphorus oxychloride to yield 1, 3, 4-thiadiazole nucleus. Further this thiadiazole was treated with different aromatic aldehydes in presence of methanol to yield corresponding Schiff’s bases. All the Schiff’s bases thus obtained were reacted with Thioglycolic acid to yield the title compounds. Synthesized derivatives were characterized by IR, H1NMR and screened for their antibacterial (S. aureus, B. subtilis, E. coli, and P. aerugiosa) and antifungal activity (A. Niger and C. albicans). Results and conclusion: The experimental data of present research work reveals that the synthesized azole derivative (1, 2, 9, and 11) demonstrates significant Antibacterial and Antifungal Activity as shown in table no. 1and out of all synthesized compounds the halogen substituted   thiazolidinones derivatives are found most active.

Keywords: Azole derivative, Benzoic acid derivative, antimicrobial activity

Manuscript Management System
Submit Article Subscribe Most Popular Articles Join as Reviewer Email Alerts Open Access
Our Another Journal
Another Journal
Call for Paper in Special Issue on

Call for Paper in Special Issue on