Sakshi Singh Chouhan*, Nadeem Farooqui, Dinesh Kumar Mishra
Department of Pharmaceutics,
Indore Institute of Pharmacy, Pithampur Road, Opposite IIM, Rau, Indore 453331 (M.P.) India
*Address for corresponding author
Sakshi Singh Chouhan
Department of Pharmaceutics,
Indore Institute of Pharmacy, Pithampur Road, Opposite IIM, Rau,
Indore 453331 (M.P.) India
Abstract
Objective: The aim of present research work was to develop and evaluate the antifungal drug loaded liposomal nail lacquer. Antifungal nail lacquer which is used in treatment of Onychomycosis nail fungal disorder, Onychomycosis is common fungal nail infection causes by the pathogens. The objective of the this formulation to enhanced permeation of luliconazole across the nail plate, delivered via liposome-dispersed nail lacquer, can be attributed to intact permeation of lipid vesicles across the nail plate due to it's a small vesicular size and also to the generated hydration force and osmotic gradient. Material and Methods: Initially liposomal suspension (LF) was prepared by Phosphatidylcholine, Cholesterol and luliconazole were dissolved in chloroform/methanol (2:1, v/v) mixture and formulated by modified film hydration technique. Then optimized formulation of liposomal suspension was further used to prepare nail formulation. Results and Conclusion: Among different formulations, the formulation (LF-8) was showed good drug entrapment - 69.61±1.09, average particle - 5.36±0.12 and zeta potential - 54.91±3.57. The optimized formulation of liposomal suspension LF-8 was further used to prepare nail formulation. The luliconazole loaded nail lacquer formulation (LLNLF-4) was showed highest In-vitro Drug Release (97.38±3.64), antifungal activity and smoothness among the other formulations. Nail lacquer is mostly applicable for those drugs which have poor bioavailability in oral formulation. This technique is used to maximize the topical bioavailability of drug across the nail.
Keywords: Nail lacquer, Luliconazole, Dimethyl Sulphoxide, Phosphatidylcholine, Isopropyl Alcohol
