Research Articles

2020  |  Vol: 6(5)  |  Issue: Articles in press  |  https://doi.org/10.31024/ajpp.2020.6.5.3
A Prospective study on symptomatic betterment of Helicobacter pylori positive patients taking standard triple therapy

Bushra Abdul Rahim1, Aleena Francis1, Arathi S. Nair1, Limi Joseph1, Soumya R.V.*, Prashobh G. R.2

1Doctor of Pharmacy Interns, Department of Pharmacy   Practice, Sree Krishna College of Pharmacy and Research Centre, Parassala, Thiruvananthapuram

2Sree Krishna College of Pharmacy and Research Centre, Parassala, Thiruvananthapuram

*Address for Corresponding Author

Soumya R.V.

Sree Krishna College of Pharmacy and Research Centre, Parassala, Thiruvananthapuram, India

Abstract

Background: Different treatment strategies are being developed and adopted from day to day in the research fields and clinical setting for helicobacter pylori infection. Aim: This study shows the effectiveness and betterment achieved by Helicobacter pylori affected individuals who followed a 14 day therapy that included 40 mg of Proton pump inhibitor (before food), 1000 mg of Amoxicillin (after food) and 500 mg of Clarithromycin (after food), each twice daily. Methods: This treatment regimen is commonly called as the Standard Triple Therapy. For this study, 90 patients were recruited and their symptomatic betterment were assessed using the GSR scale that were administered twice to the patients- prior to the initiation of the treatment and after the completion of the treatment. Results: After the successful treatment of 88 patients, an overall symptom reduction by 93.2% was observed. For better understanding the symptoms scores were categorized into reflux score, abdominal pain score, indigestion score, diarrhoea sore and constipation score. And a reduction of these symptoms by 90.9%, 86.4%, 92%, 90.9% and 90.9% respectively were observed. Conclusion: This study contradicts many other studies that showed a better effectiveness of sequential therapy over standard triple therapy in H. pylori positive patients.

Keywords: Symptomatic betterment, standard triple therapy, Helicobacter pylori

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