Research Articles

2019  |  Vol: 5(5)  |  Issue: 5(September- October)  |
Safety and effectiveness of intravenous vitamin B combination in chronic kidney disease patients with hyperhomocysteinemia

Rizaldy Taslim Pinzon1, Esdras Ardi Pramudita2, Rosa De Lima Renita Sanyasi2*

1Bethesda Hospital, Yogyakarta, Indonesia

2Panti Rapih Hospital, Yogyakarta, Indonesia

*Address for Corresponding Author

Rosa De Lima Renita Sanyasi

Panti Rapih Hospital, Cik Di Tiro Street No. 30, Yogyakarta, Indonesia, 55223


Background: Hyperhomocysteinemia may be associated with increased morbidity and mortality from cardiovascular disease in chronic kidney disease (CKD) patients. Previous study stated vitamin B supplementation effectively reduce homocysteine levels. Objective: This study aimed to identify the safety and effectiveness of intravenous vitamin B combination to reduce homocystein level in patients with CKD. Material and Methodss: This was an observational non control study. Subjects were male or female, >18 years, and has a CKD with a routine hemodyalisis two times per week. Every subject has a routine vitamin B combination injection. The vitamin B combination consist of 100 mg vitamin B1, 100 mg vitamin B6, and 5000 mcg vitamin B12. It injected intravenously after each hemodyalisis. The shifting of homocysteine level from the first week to the second week described as delta (Δ) homocysteine. Results: Homocysteine level was measured at baseline, second, and fourth week. The percentage of hyperhomocysteinemia and the mean of homocysteine level were decreasing from baseline (89.3%; mean 23.43±8.39 µmol/L) to the last visit (20.5%; mean 12.24±4.41 µmol/L). A significant reduction was seen in Δ homocysteine 1-2 (p:0.009) and Δ homocysteine 1-4 (p:0.008). Observasion of adverse event was made at the second and the fourth week. There were two subjects who had an adverse event during this study at the second week. After a further investigation, the adverse events concluded to be not correlate to the administration of intravenous vitamin B combination. Conclusion: Vitamin B combination proven to be effective and safe to reduce the homocysteine level in CKD patients.

Keywords: chronic kidney disease, hemodyalisis, homocysteine, vitamin B

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