Research Articles

2021  |  Vol: 7(1)  |  Issue: 1(January-February)  |  https://doi.org/10.31024/ajpp.2021.7.1.1
Antimicrobial, molecular docking and in vitro SAR studies of pyrazole clubbed imino phenyl derivatives

Paleri Veetil Sandhya1*, Kakkottakath Valappil Muhammad Niyas2

1Department of Chemistry, Govt. Residential Women's Polytechnic College, Payyanur, Kannur, Kerala, 670307 India

2Department of Chemistry, Govt. Brennan College, Thalasseri, Kannur, Kerala, India

*Address for the Corresponding Author

Sandhya P. V.

Assistant Professor in Chemistry

Govt. Residential Women's Polytechnic College, Payyanur, (P.O) Korom, Kannyr, Kerala, 670307 India

 

Abstract

Objective: Pyrazoles are well known five membered heterocyclic compounds. Pyrazoles and its derivatives have excellent biological activities which cause intensive interest in scientists, especially in the synthesis and investigation of its biological activities such as antibacterial, antifungal, antiviral and anti-inflammatory. The objective of present study was to synthesis the compounds containing both imino group and pyrazole ring and investigation of their biological activity. Materials and methods: The five membered cyclic nitrogen containing compounds exhibiting a broad spectrum of biological activities such as antioxidant, analgesic, antibacterial, antifungal activities. The in cooperation of imino or azo group into this compound might have been enhanced its biological activities. Therefor here we focused to synthesis the compounds containing both imino group and pyrazole ring as nitrogen containing heterocyclic compounds. The structure of all the synthesized pyrazole clubbed imino compounds confirmed by different spectroscopic techniques and their biological activities were screened. Molecular docking studies were examined by the software Arguslab 4.0.1. Results: The synthesized compounds showed good to moderate biological activities both experimentally and theoretically. Conclusion: Most of the synthesized compounds bearing electron withdrawing group at para position of phenyl group were found to be exhibiting more biological activities.  Molecular docking studies also supported the findings.

Keywords: 1,3-Diphenyl pyrazol-4-carboxaldehyde, antibacterial activity, antifungal, Vilsmeir -Haack reaction, molecular docking, alamar blue assay

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