Research Articles

2018  |  Vol: 4(6)  |  Issue: 6 (November-December)  |  https://doi.org/10.31024/ajpp.2018.4.6.18
Evaluation for protective role of quercetin on gemcitabine-induced lipid peroxidation using common laboratory markers

Sarbani Dey Ray

Department of Pharmaceutical Sciences, Assam University, Silchar 788011, India

*Address for Corresponding Author

Sarbani Dey Ray

Department of Pharmaceutical Sciences, Assam University, Silchar 788011, India

Abstract

Objective: The work was designed is to explore the protective role of quercetin on gemcitabine-induced lipid peroxidation. Material and methods: The in vitro study was carried out using goat liver as model lipid source. Two common laboratory markers such as malondialdehyde and reduced glutathione were used for the model. Results and conclusion: The results showed that gemcitabine has the ability to induce lipid peroxidation to a significant extent and it was also found that quercetin has the ability to suppress the gemcitabine-induced toxicity. 

Keywords: Gemcitabine, quercetin, lipid peroxidation, malondialdehyde, reduced glutathione

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