Nandini Hingwasia1, Salaj Khare1*, B K Dubey2, Amit Joshi1, Suresh Dhakad1, Amit Jain1
1TIT- Pharmacy Education and Research, Anand Nagar, Bhopal, M.P. India
2Technocrats Institute of Technology- Pharmacy, Anand Nagar, Bhopal, M.P. India
TIT- Pharmacy Education & Research, Anand Nagar, Bhopal-462021, (M.P.) India
Objective: The aim of the present study is to evaluate the anti-diabetic activity of hydroalcoholic extract of bark of Feronia limonia on alloxan induced rats. The plant belongs to family Rutaceae , is an angiosperm with various medicinal properties including anti-diabetic, anti-bacterial, anti-inflammatory, hepatoprotective, anti-oxidant, muscle relaxant, larvicidal and anti-tumour. Bark extract principally showed the presence of flavonoids and phenols. Materials and methods: Alloxan (120 mg/kg) was dissolved in saline and administered intravenously into fasted rats. The animals were divided into 4 groups randomly consisting of 6 rats in each group as follows: group 1 (normal control) includes non- alloxanized rats (0.5% normal saline, 5 ml/kg body weight orally for 21 days), group 2(positive control) untreated diabetic control (0.5 ml/100 gm normal saline), group 3 (standard) diabetic rats treated with reference drug glibenclamide 5 mg/kg p.o. for 21 days and group 4 (test) diabetic rats treated with test drug 300 mg/kg for 21 days. Results: At the end of 21st day, blood glucose level and lipid profile was found to be effectively reduced as compared to glibenclamide. Histopathological study was carried out which reveals disturbances in pancreatic cells i.e. positive control group was found to have pronounced edema whereas normal group resembles test in having minimum edema. Conclusion: Thus, it can be concluded from above that Feronia limonia bark extract is found to be efficacious in reducing BGL and lipid levels.
Keywords: Feronia limonia, Rutaceae, anti-diabetic, flavonoids, glibenclamide