Research Articles

2018  |  Vol: 4(1)  |  Issue: 1(January-February)  |  https://doi.org/10.31024/ajpp.2018.4.1.10
Hepatoprotective and antidyslipidemic effect of Ferula asafoetida in CCl4 induced hepatotoxicity and CCl4 associated dyslipidemia in rats

Vaishali Sharma, Shradha Bisht*, Mamta F. Singh

Department of Pharmaceutical Sciences

SBS PG Institute of Biomedical Sciences and Research, Balawala, Dehradun, Uttarakhand, India

*Corresponding author

Dr. Shradha Bisht

Department of Pharmaceutical Sciences

SBS PG Institute of Biomedical Sciences and Research, Balawala, Dehradun, Uttarakhand, India

Phone: +919639369930

Abstract

Objective: The present study was conducted to evaluate hepatoprotective and antidyslipidemic activity of aqueous extract of Ferula asafoetida in CCl4 induced hepatotoxicity and associated dyslipidemia and oxidative stress in rats. Material and methods:  Hepatotoxicity was induced by administration of CCl4 (1mg/kg) in alternate days for a period of 14 days.  The animals were divided into 6 groups and aqueous extract of F. asafoetida at dose level of 50mg/kg, 100 mg/kg and 200 mg/kg was administered respectively for 21 days. Liv-52 (1ml/kg) was used as the standard drug.  At the end day of the experiment, the blood was collected by retro-orbital puncture and the hepatoprotective effect was evaluated by analyzing biochemical parameters involved in liver damage. Result: The extract was effective in protecting the liver against the injury induced by CCl4 in rats. This was evident from significant reduction in serum glutamic-pyruvic transaminase (SGPT), serum glutamic oxaloacetic transaminase (SGOT) and total bilirubin content. The extract revealed antioxidant and antihyperlipidemic activity too. Conclusion: It was concluded from the result that the aqueous extract of asafoetida possesses hepatoprotective activity against CCl4 induced hepatotoxicity in rats and also play a beneficial role in CCl4 associated dyslipidemia and status of oxidative stress.

Key words:  Asafoetida, hepatoprotective, liver enzymes, lipid profile, oxidative stress

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