Review Articles

2020  |  Vol: 6(3)  |  Issue: 3 (May- June)  |
COVID-19 infection: Does BCG Vaccine offers any protection

Savita Ramesh Shahani1*, Lokesh R. Shahani2

1Pharmacology Department, MGM Medical College Navi Mumbai, Maharashtra, India

2Louis A. Faillace, MD, Department of Psychiatry and Behavioral Sciences at McGovern Medical School, Houston, Texas 77054

*Address for Corresponding Author

Savita Ramesh Shahani

Professor, Pharmacology Department, MGM Medical College Navi Mumbai, Maharashtra, India



COVID-19 virus which is a single stranded RNA virus was responsible for infections first seen in Wuhan city in china and reached to stage of pandemic. World Health Organization (WHO) recommended use of antiviral drug therapy either alone or in combination with interferon. Interferon probably acts via alerting the cellular immune system to viral infection of host cells. Even though BCG vaccine was developed to combat tuberculosis (TB), the mortality benefit from BCG is not TB-specific but can be effective against some other organisms. Some of the unconfirmed observations and even meta-analysis of data indicate that COVID 19 pandemic is less intense in the countries with BCG vaccine intervention. Based on these data many clinical trials are being started to confirm protective effect of BCG vaccine against COVID-19 infection. However WHO stated in a press briefing that multitudes of confounding variables prevent to reach to any firm correlations. However, WHO has not ruled out the fact that the vaccine may exhibit positive effects in protecting COVID- 19 infection or reducing its severity but in absence of evidence, WHO does not recommend BCG vaccination for the prevention of COVID-19 BCG Vaccination COVID-19 Immune system WHO.

Keywords: BCG vaccination COVID-19, immune system, World Health Organization

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