Kiran B. Kotade*1, Shivanand N. Hiremath2
1Shri J.J.T. University, Jhunjhunu, Rajasthan, India -333001
2P.R.E.S.’s, Pravara College of D Pharmacy, Loni, Ahmednagar, Maharashtra, India-413736
*Address for Corresponding Author
Kiran B. Kotade
Shri J.J.T. University, Jhunjhunu, Rajasthan, India -333001
Objective: The objective of present study is to systematically investigate and confirm the folklore use of Gymnospora Montana fruits in different models of ulcer. Materials & methods: The ethanolic extract of Gymnospora montana fruit were selected and equipped in doses of 100 and 500 mg/kg. The antiulcer activity of Gymnospora montana was evaluated by aspirin induced ulcers, pyloric ligation models and Cysteamine induced ulcers. Results: It was revealed that ethanolic extract had marked antiulcer activity in all these models at a dose of 500 mg/kg. In addition, it was also found to increase the mucin content of the gastric mucosa. The observed results were attributed to the rich content of flavonoids in the ethanolic extract. Conclusion: The present study affords a significant contribution in confirmation of the forklore effects of a traditional remedy.
Keywords: Gymnospora montana, Shay rats, duodenal ulcer, peptic ulcer, flavanoids