Department of Pharmacology, Osmania Medical College, Koti, Hyderabad, India
*Address for Corresponding Author
Dr. S. Thurka
Department of Pharmacology, Osmania Medical College, Koti, Hyderabad-500095, India
Objective: Atopic dermatitis is a chronic, itchy, inflammatory skin disease. It can significantly impact the quality of life of affected individuals and their families. The aim of this study is to compare and evaluate the efficacy and safety of topical Mometasone Furoate 0.1% ointment versus topical Tacrolimus 0.03% ointment in the treatment of atopic dermatitis. Material and Methods: A prospective, open-label, comparative study was conducted at the Osmania General Hospital, Hyderabad, Telangana. Sixty patients clinically diagnosed with atopic dermatitis were simply randomized, of whom Group 1 received topical Mometasone Furoate 0.1% ointment twice daily, and Group 2 received topical Tacrolimus 0.03% ointment twice daily for 12 weeks. The Scoring of Atopic Dermatitis (SCORAD) index was used to assess the severity of the disease. The mean reduction in the SCORAD index was compared with baseline and after 12 weeks. Patients were followed up every month for a period of 3 months. A safety assessment was done according to adverse events reported or noted during the study. Results: Out of the 60 patients included in the study, 48.33% were males and 51.66% were females. Before treatment, the respective mean SCORAD was 33.16 ±5.7 & 33.37±5.48 in groups A and B and at the end of treatment it decreased to 15.5 ±3.82 & 14.8 ± 3.40 respectively. There is no statistical significance in the mean SCORAD reduction between the groups [p=0.45]. Conclusion: Mometasone Furoate and Tacrolimus are equally effective in the treatment of atopic dermatitis. Serious or new adverse events were not reported.
Keywords: Atopic dermatitis, mometasone furoate, tacrolimus, Telangana