Mruthyunjaya Devika1, Monnanda Somaiah Nalini2*
1Department of Botany, Sarada Vilas College, Krishnamurthypuram, Mysore-570 004, Karnataka, India
2Department of Studies in Botany, University of Mysore, Manasagangotri, Mysore-570 006, Karnataka, India
Dr. Monnanda Somaiah Nalini,
Department of Studies in Botany, University of Mysore
Manasagangothri, Mysore- 570 006, Karnataka, India.
Objective: The objective of the present study was to evaluate the anxiolytic potentials of the leaf and stem bark aqueous and ethanol extracts of Litsea floribunda (LF) using EPM and LDT in mice. Materials and methods: Albino mice were treated with extracts of LF (100 and 200 mg/kg, p.o.) and standard drug Diazepam (20 mg/kg, i.p.) for 14 days and after last dose administration on 14th day, all behavioural studies were performed and evaluated. Results and conclusion: The standard drug Diazepam increased the time spent in light arm in EPM model and light chamber in LDT model. In EPM model the anxiolytic effect was exhibited by group III, IV (ethanolic leaf extract 100 and 200 mg/kg), VI (aqueous leaf extract 200 mg/kg), VII (ethanolic stem bark extract 100 mg/kg), IX and X (aqueous stem bark extracts 100 & 200 mg/kg) was comparable to that of group III i.e. standard drug diazepam where as in LDT model, the anxiolytic effect exhibited by III, IV (ethanolic leaf extract 100 and 200 mg/kg), V (aqueous leaf extract 100 mg/kg), VII (ethanolic stem bark extract 100 mg/kg), IX and X (aqueous stem bark extracts 100 & 200 mg/kg) groups was comparable to that of standard drug diazepam. In conclusion LF extracts possessed potential anxiolytic effects which could be of therapeutic interest for using in the treatment of anxiety disorders.
Keywords: Anxiolytic, Litsea floribunda, ethanol, aqueous extracts, Diazepam