Jitendra Kumar, Basavaraj C. Koti*, Neelakanth M. Jeedi
Department of Pharmacology, KLE College of Pharmacy, Hubballi, Karnataka, India (580031).
*Address for Correspondence Address
Basavaraj C. Koti
Department of Pharmacology, KLE College of Pharmacy, Hubballi, Karnataka, India-580031
Objective: Objective of present research work was to evaluate the effect of Canthium parviflorum on experimentally induced ulcer in rats. Materials and methods: Ethanolic extract of leaves of plant Canthium parviflorum (EECP) were investigated for the presence of various phytoconstituents. Antiulcer activity of EECP was carried out by ulcerogenic pylorus ligation, aspirin and cold stress induced rat models. EECP 100, 200 mg/kg and standard drug ranitidine 20 mg/kg body weight dose administered orally 30 min prior to induction of ulcer. Biochemical parameters namely pH, free acidity, volume of gastric juice, mucin, total acidity, pepsin and protein contents were accounted to asses antiulcer activity. Further, Histopathological study of gastric mucosa was carried out. Results: Experimental data indicate that EECP reduces the gastric secretion, its free acidity and total acidity level was less, but its pH level was more. It was observed that extract increases the level of protective factor like mucin but reduces the aggressive factor like pepsin dose dependently. Conclusion: The present finding suggests that leaves of Canthium parviflorum possess anti-ulcer property.
Keywords: Canthium parviflorum, antiulcer, antisecretory, ulcer index, ranitidine