Nagesh J. Deshmukh, Gajanan D. Kottapalle, Avinash T. Shinde*
PG research center department of Chemistry, N.E.S. Science College, Nanded. (Maharashtra)- 431602 (India)
*Address for Corresponding Author
Avinash T. Shinde
PG Research Center Department of Chemistry, N.E.S. Science College, Nanded. (Maharashtra)- 431602 (India)
Objectives: The chemistry of chalcones has generated intensive scientific studies throughout the world. Especially interest has been focused on the synthesis and biodynamic activities of isoxazoline derivatives. In recent year numerous isoxazoline derivatives have been synthesized for their anticancer, anti-inflammatory, cytotoxic, antiviral activities. The reaction of substituted chalcones with hydroxylamine hydrochloride in presence of acetic acid gave isoxazoline derivatives. Material and methods: The five membered oxygen and Nitrogen containing compounds exhibited antioxidant, analgesic, antibacterial, antifungal activities. Therefore the attempt have been made to synthesize chloro-substituted isoxazolines by the reaction of different substituted chalcones with hydroxylamine hydrochloride in presence of few drops of acetic acid. All the synthesized compounds confirmed by TLC and spectral analysis and also screened for their antibacterial activity. Results: The novel chloro-substituted isoxazolines showed good to moderate antibacterial activity against Gram+ve and Gram –ve bacterial strains tested. Conclusion: These compounds containing chloro, bromo, iodo groups were found showed potent antibacterial, antifungal activities. These findings promoted us to to synthesize novel chloro-substituted isoxazolines derivatives which are found to be potential antibacterial agents.
Keywords: Chalcones, hydroxylamine hydrochloride, isoxazolines, antibacterial activity