Research Articles

2018  |  Vol: 4(6)  |  Issue: 6 (November-December)  |  https://doi.org/10.31024/ajpp.2018.4.6.8
Identification of potent Cyanoacetylhydrazone derivatives as antidiabetic activity by in silico method

K. Sundaresan, K. Tharini*

Department of Chemistry, Government Arts College, Trichy-22, TamilNadu, India

*Address for Corresponding Author

K. Tharini

Department of Chemistry, Government Arts College, Trichy-22, TamilNadu, India

Abstract

Objective: The high diabetic mellitus rate in India, the identification of novel molecules is important in the development of novel and potent antidiabetic drugs. Herein, novel series of acetohydrazide derivatives were analyzed for antidiabetic activity using combined approach of molecular docking study and ADMET (computational pharmacokinetic elucidation). Material and methods: The in silico molecular docking study and ADMET calculation were carried out using BIOVIA Discovery Studio (DS) 2017 software. Results and conclusion: The molecular interaction analysis revealed that the compounds have good interaction with the active site of 1IR3. The ADMET results show these molecules contain drug likeness properties. So this examination would be an approach to recognize new therapeutics for diabetic patients.

Keywords: Anti-diabetic, Molecular docking, ADMET, insulin receptor

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