Research Articles

2019  |  Vol: 5  |  Issue: Articles in press
Antiulcer activity of ethanolic extract of Sesamum Indicum on experimental animal models

Arun Kumar1*, Nitin Kumar2, Rahul Shukla1, Anurag Chaudhary3

1School of Pharmaceutical Sciences, Sri Venkateswara University, Gajraula, U.P. 244236 India

2Department of Pharmacy, Its College Of Pharmacy, Muradnagar, Ghaziabad- 201206, India

3Meerut Institute of Engineering & Technology, Department of Pharmaceutical Technology, Baghpat bypass crossing, N.H. 58, Delhi-Haridwar Highway, Meerut-250005, India

*Address for corresponding author:

Arun Kumar,

School of Pharmaceutical Sciences, Sri Venkateswara University, Gajraula, U.P. 244236 India

Abstract

Objective: Gastroprotective effect of 70% ethanolic extract of Sesamum indicum L. (Black sesame) (Pedaliaceae) seeds and aerial parts have been assessed in different acute and chronic gastric ulcer models in rats. Material and Methods: Extract was administered orally (100, 200 and 400 mg/kg body weight rats), twice daily for 5 days for prevention from ethanol and 10 days for prevention of acetic acid induced ulcers. EESI showed dose dependent inhibition of ulcer index in ethanol and acetic- acid induced ulcers. EESI prevents the oxidative damage of gastric mucosa by blocking lipid peroxidation and by significant decrease in superoxide dismutase, and increase in catalase activity. Results: Extract showed dose dependent inhibition of ulcer index in ethanol and acetic acid – induced ulcers. Extract prevents the oxidative damage of gastric mucosa by blocking lipid peroxidation and by significant decrease in superoxide dismutase, and increase in catalase activity. Conclusions: Results showed that Sesamum indicum possesses significant gastroprotective activity which might be due to gastric defence factors.

Keywords: Sesamum indicum L; Anti-ulcer; Antioxidant; Gastroprotective; Lipid peroxidation

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