Research Articles

2019  |  Vol: 5(3)  |  Issue: 3 (May- June)  |
Evaluation of wound healing potential of Nerium indicum, Artocarpus heterophyllus, Murraya koenigii and Punica granatum using incision wound model in rats

Renuka Shukla, Varsha Kashaw*

SVN Institute of Pharmaceutical Sciences, Swami Vivekanand University, Sagar, Madhya Pradesh, India

*Address for Corresponding Author:

Dr. (Mrs.) Varsha Kashaw


SVN Institute of Pharmaceutical Sciences,

Swami Vivekananda University, Sagar (M.P.) India


Objective: The objective of present work was to assess the wound healing potential of Nerium indicumArtocarpus heterophyllus, Murraya koenigii and Punica granatum formulated as poly-herbal ointment and gel using Incision wound model in albino rats. These plants exhibit anti-diabetic, anti-inflammatory, anti-microbial, anti-leukemic, anti-mycobacterial, antioxidant, antitumor, antiulcer, antiviral, anticancer, antimalarial, cytotoxic, anti-protozoal and wound healing properties. Materials and Methods: Solvent extraction method was used for extraction of plant material for further processing into different formulations. Poly-herbal ointment and gel formulation were prepared by mixing the extract of Nerium indicumArtocarpus heterophyllus, Murraya koenigii and Punica granatum. Incision wound model on albino rats was used for the assessment of wound healing potential. Results and Conclusion: The studies on incision wound healing model reveals that F2 poly-herbal ointment formulation show better wound healing potential in comparison to gel formulation as well as all extracts of the plants and there was no mortality observed in the course of study. These studies has indicated that ointment and gel poly-herbal formulation of Nerium indicum, Artocarpus heterophyllus, Murraya koenigii and Punica granatum has been utilized for wound healing and it is safer for topical application. No toxicity and mortality has been observed during the experimental tenure. 

Keywords: Wound healing, Nerium indicum, Artocarpus heterophyllus, Murraya koenigii, Punica granatum, incision wound model

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