Review Articles

2020  |  Vol: 6(3)  |  Issue: 3 (May- June)  |  https://doi.org/10.31024/ajpp.2020.6.3.10
Poly (propylene imine) Dendrimer: Synthesis, characterization and applications in various drug delivery

Neeharika Gogulapati*, Balasubramanian Valli Manalan, Rama Rao Nadendla

Department of Pharmaceutics, Chalapathi Institute of Pharmaceutical Sciences, Lam, Guntur 522034, Andhra Pradesh, India

*Address for Corresponding Author

Neeharika Gogulapati

Department of Pharmaceutics, Chalapathi Institute of Pharmaceutical Sciences, Lam, Guntur 522034, Andhra Pradesh, India


Abstract

Dendrimers are a novel class of macromolecule having highly repetitively branched molecules consists of a monomer unit. Dendrimer consists of a tree like shaped structure. Dendrimer composed of initial core, interior layers (generations) and exterior (terminal functional group). Types of dendrimers, examples: Poly (propylene imine) dendrimer (PPI), Poly (amidoamine) dendrimers (PAMAM), Radially layered Poly (amidoamine – organosilicon) dendrimers (PAMAMOS) etc. The properties of dendrimers are determined by monodispersity, size and shape, rheological property, crystallinity, immunogenicity and cytotoxicity. Synthesis of dendrimers is convergent method, divergent method and double exponential and mixed growth. The major applications of dendrimers are: Pharmaceutical applications, therapeutic applications, diagnostic applications, dendritic catalyst/enzyme, industrial process, and current and potential applications of dendrimers. This review focus on dendrimer structure, advantages, types, properties, characterization, synthesis, mechanism, other forms of dendrimers, applications of dendrimers and the mainly focus on PPI dendrimers.

Keywords: Dendrimer, Poly (propylene imine) dendrimer, Poly (amidoamine) dendrimers, Poly (amidoamine – organosilicon) dendrimers, convergent, divergent

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