Research Articles

2019  |  Vol: 5(1)  |  Issue: 1(January-February)  |  https://doi.org/10.31024/ajpp.2019.5.1.21
Reducing power and superoxide radical scavenging activity of a triterpene derivative isolated from root bark of Zizyphus nummularia Aubrev

Sarbani Dey Ray1, 2

1Department of Pharmaceutical Sciences, Assam University, Silchar, Assam, India,

2Dr. B. C. Roy College of Pharmacy & A.H.S, Durgapur, West Bengal, India

*Address for Corresponding author

Sarbani Dey Ray

Department of Pharmaceutical Sciences, Assam University, Silchar, Assam, India

Abstract

Objective: The aim of the study is to investigate the reducing power and superoxide radical scavenging activity of the ethanolic extract (EE) and an identified lead compound (LC) which is a triterpene derivative isolated from root bark of Zizyphus nummulariaMaterial and methods: The in vitro evaluation of antioxidant activities of ethanolic extract (EE) and an identified lead compound (LC) was done by measuring reducing power, superoxide radical. Results and conclusion: The result showed that the reducing power and superoxide radical scavenging activity of EE, LC followed a dose dependent pattern. The IC50 values for LC are comparatively lower than EE. So, the study showed that EE and LC of Z. nummularia have potent reducing power and superoxide radical inhibitory activity.

KeywordsZizyphus nummularia, reducing power, superoxide radical, Octadecahydro-picene-2,3-14-15-tetranone

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