Review Article

2020  |  Vol: 6(5)  |  Issue: Articles in press  |  https://doi.org/10.31024/ajpp.2020.6.5.5
Pharmacotherapy for COVID-19

Princy Louis Palatty1, Satyajith Nair2, Rosme David1, Mamatha J.1, Vanditha S.1, Deepthi Mary George1, Savithri P.1, P. G. Nayar1*

1Department of Pharmacology, Amrita Vishwa Vidyapeetham, Health Sciences Campus, Amrita Institute of Medical Sciences, Elamakkara P.O., Kochi - 682 041 Kerala, India

2Department of Pediatrics, Amrita Vishwa Vidyapeetham, Health Sciences Campus, Amrita Institute of Medical Sciences, Elamakkara P.O., Kochi - 682 041 Kerala, India

*Address for Corresponding Author

Dr. P. G. Nayar

Nodal Officer, Ex-Professor

Department of Pharmacology, 

Amrita Vishwa Vidyapeetham, Health Sciences Campus, Amrita Institute of Medical Sciences, Elamakkara P.O., Kochi - 682 041 Kerala, India

Abstract

The past few months has witnessed mankind facing one of its toughest battles for survival till date. Severe acute respiratory syndrome caused by SARS CoV 2 has demonstrated its ability to bring humans to their knees at an unprecedented speed with no drugs or vaccine available till date. The objective of our review is to explore and compile the various drugs tried for the Corona virus disease 19 across the world. We had vast literature search and shortlisted 164 articles. The drugs tried for the covid -19 are given under category A, B and C. Category A need symptomatic treatment. Category B is given hydroxy chloroquine, azithromycin, and oseltamivir, Category C with hydroxy chloroquine and favipiravir. If favipiravir is contraindicated/not available, then hydroxychloroquine with either azithromycin or lopinavir/ritonavir for 14 days or 7 days after becoming asymptomatic is tried. In the Category C - moderate severity, Injection Remdesivir plus Injection Methyl prednisolone/Injection Dexamethasone is to be given. Patients with severe signs and symptoms (Respiratory Rate ≥ 30, SpO2 < 90 on room air) are suggest being initiated with Injection Remdesivir plus Injection Methyl prednisolone/Injection Dexamethasone. Convalescent plasma therapy to be initiated as per the respective state wise protocol in India. What we conclude is that, we advocates and describes the regimens used in everchanging guidelines for covid therapy in different part of the world and a special attention to symptomatic approach to treat the covid 19 disease in children has also been covered in this review article.

Keywords: corona virus disease 19, regional guidelines, convalescent plasma, heparin, corticosteroids, remdesivir

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