Research Articles

2019  |  Vol: 5(2)  |  Issue: 2(March-April)  |  https://doi.org/10.31024/ajpp.2019.5.2.26
Evaluation of wound healing prospective of Momordica charantia, Pongamia glabra and Piper nigrum on anemic albino rats using incision wound model

Rashmi Shukla, Varsha Kashaw*

SVN Institute of Pharmaceutical Sciences, Swami Vivekanand University, Sagar, Madhya Pradesh, India

*Address for Corresponding Author:

Dr. (Mrs.) Varsha Kashaw

Professor

SVN Institute of Pharmaceutical Sciences, Swami Vivekananda University, Sagar (M.P.) India

Abstract

Objective: The objective of present work was to evaluate wound healing potential of Momordica charantiaPongamia glabra and Piper nigrum using as herbal ointment formulation on albino rats using incision wound model. These plants were contain alkaloidal, glycoside and flavonoid derivatives and were used as anti-diabetic, anti-inflammatory, antitumor, anti-malarial and having wound healing potential. Materials and Methods: Extract of all three plants has been separated by the Soxhlet extraction. Herbal ointment formulation has been prepared by mixing the extract of Momordica charantiaPongamia glabra and Piper nigrum with the wool fat and paraffin. Incision wound model has been utilized for the evaluation of wound healing potential. Histopathological evaluation has been also carried-out. Results and Conclusion: The studies on incision wound healing model reveals that all twelve groups showed decreased wound area on the time and there was no mortality observed in the course of study. Discussion: These studies have indicated that herbal ointment formulation of Momordica charantiaPongamia glabra and Piper nigrum has been utilized for wound healing and it is safer for topical application. No toxicity and mortality has been observed during the experimental tenure. 

Keywords: Wound healing, Momordica charantiaPongamia glabraPiper nigrum, incision wound model

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