Research Articles

2020  |  Vol: 6(4)  |  Issue: 4 (July- August)  |  https://doi.org/10.31024/ajpp.2020.6.4.3
Pharmacological evaluation of clove oil emulsion on propylthiouracil induced hypothyroidism in wistar rats

Harshada Lanjekar*, Swati Kolhe, Sachin Tembhurne

Department of Pharmacology, AISSMS College of Pharmacy, Pune-411001 India

*Address for Corresponding Author

Harshada Lanjekar

Department of Pharmacology, AISSMS College of Pharmacy, Pune-411001 India

 

Abstract

Objective: The present work was carried out to evaluate the effect of clove oil for enhancing thyroid function. Material and methods: Wistar rats received propylthiouracil at a dose 0.3mg/kg/bw (orally) daily for 21 days as pretreatment for induction of hypothyroidism and after induction treated with clove oil emulsion at dose 100, 200 and 300 mg/kg (orally) daily for 21 days. All animals were observed throughout the whole experiments and note down body weight of each animal once in week. Blood samples were taken before and after treatment and hormonal level assay was performed. Histopathological analysis was also assessed. Results and conclusion: Significantly increase value of T3, T4 and compared with control, standard and test value. Histopathological changes were observed with few vacuolation. It was concluded that clove oil emulsion plays vital role on propylthiouracil (PTU) induced hypothyroidism by enhancing thyroid functions in experimental wistar rats.

KeywordsPropylthiouracil (PTU), clove oil, emulsion, hypothyroidism

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