Research Articles

2019  |  Vol: 5(5)  |  Issue: 5(September- October)  |  https://doi.org/10.31024/ajpp.2019.5.5.4
Evaluation of anti-anxiety activity of Cocos nucifera endocarp on anxiety models

Virupanagouda P. Patil1, Nanjappaiah Hankuntimath1, Chandrashekhar Venkaraddi Mangannavar2, Shivakumar Hugar1*

1P.G. Department of Pharmacology, BLDEA’s SSM College of Pharmacy and Research Centre, Vijayapur-586103. Karnataka. India.

2P.G. Department of Pharmacology, BVVS’s HSK College of Pharmacy, Bagalkot- 587101. Karnataka. India.

*Address for Corresponding Author

Dr. Shivakumar Hugar

Prof. and Head, P.G. Department of Pharmacology,

BLDEA’s SSM College of Pharmacy and Research Centre, Vijayapur-586103

Karnataka. India

Abstract

Objective: Current study deals with the anti-anxiety effect of ethanolic extract of Cocos nucifera endocarp in anxiety models. Materials and Methods: Anxiolytic effect of C.nucifera endocarp at the dose of 125, 250 and 500 mg/kg evaluated using validated models such as elevated plus maze test, open field apparatus test and light/dark exploration test in mice. Results: In the EPM, test extract at 250 and 500 mg/kg significantly increased the number of entries and time spent in open arms. In the OFT, C.nucifera endocarp extract significantly increases, the rearings and square crossings. In the LDT, title plant significantly increased the time spent in light chamber, number of crossings and duration of immobility was reduced. Conclusion: From our study, it can be concluded that ethanolic extract of Cocos nucifera endocarp at the dose of 250 and 500 mg/kg possesses marked anti-anxiety effect.

KeywordsCocos nucifera, anti-anxiety, elevated plus maze test

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