Urmistha Sarkar, Anusree Raha, Prosenjit Mukherjee, Monit Paul, Anindya Bagchi
Netaji Subhas Chandra Bose institute of Pharmacy, Chakdaha, Nadia, West Bengal, India.
*Address for Corresponding Author
Netaji Subhas Chandra Bose Institute of Pharmacy, West Bengal, India
Objective: The purpose of the present study was to develop and evaluate the topical gel containing metronidazole using different gelling agents such as hydroxy methyl propyl Cellulose, Na-alginate, and Na-CMC in variable concentrations. Material and Methods: Nine formulated gels were prepared and evaluated physically in terms of colour, odour, homogeneity, pH, spreadibility, tube extrudability, drug content and in vitro diffusion study. Results: The results revealed that the surface pH of nine gel formulations were within the natural skin pH range, among them sodium alginate formulations (F4, F5, F6) showed exact skin pH. Drug content was high (76.38%) in HPMC gels and In-vitro release study indicated that % released at 180 minutes is 23.37%. Drug release from the HPMC gels increased with the addition of PG. In case of gels containing HPMC, Na-alginate, Na-CMC as gelling agents, additions of PG increased the release of drug from the gels. Also antibacterial spectrum have been measured for the Formulation called F3 which showed good result after comparing with marketed formulation. Conclusion: It can be concluded that PG is a good penetration enhancer and HPMC good gelling agent for metronidazole gels.
Keywords: Metronidazole, topical gel, HPMC, Na-Carboxy methyl cellulose, Na-alginate, spreadibility