Megha Kolte, Rajesh Singh Pawar*
Truba Institute of Pharmacy, Karond, Bhopal, 462038, Madhya Pradesh, India
*Address for Corresponding Author
Dr. Rajesh Singh Pawar
Professor and Principal
Truba Institute of Pharmacy, Karond, Bhopal, 462038, Madhya Pradesh, India
Abstract
Background: Skin cancer is the leading type of cancer worldwide. It remains challenge to researcher to develop potent anticancer drug. 5-fluorouracil is potent anticancer drug. Objective: In this work we formulated 5-FU loaded nanosponge of and evaluated the formulation for the treatment of skin cancer. Material and methods: Formulated nanosponge pass through the skin and showed potent therapeutic effect at the application site. Six formulations of nano-sponges were evaluated for entrapment efficiency, Zeta potential and SEM. Results and Conclusion: Formulation F4 showed better entrapment of drug, so it was further used for gel formulation. Carbopol was incorporated in nanosponge gel and prepared 4 formulations. All of these four formulations were evaluated for different parameters like pH determination, viscosity, spreadibility, drug content and in vitro drug release. Formulation G3 was contains 94% drug and drug release was found to be 92%.
Keywords: 5-Fluorouracil, skin cancer, nano sponge gel, carbopol
