Muhamad Ibrahim A., A. Nagarajan*, Muhammed Majeed
R&D Centre, Sami Labs Limited, 19/1 & 19/2, Ist Main, IInd Phase, Peenya Industrial Area, Bangalore -58 India
*Address for Corresponding Author
Dr. A. Nagarajan
Vice President – R&D, R&D Centre, Sami Labs Ltd,
Peenya Industrial Area, Bangalore, India
Objective: To explore the wound healing activity of Enicostema littorale leaf extract (Gentianaceae). Materials and Methods: Ethanolic leaf extract and its active secoiridoid, Swertiamarin are used for this study. There is a significant wound healing activity observed for the group of Wistar rats treated with Swertiamarin. Scientific cure is proven by measuring the wound area in each test group animals from 0 to 15 days. Results: The topical application of ethanolic extract and Swertiamarin ointment results in decrease of the wound area in 15 days. Swertiamarin is effective in comparison with crude ethanolic extract. Biological estimation also proved that the Swertiamarin treated group had a high percentage of wound contraction score than the control group. Conclusion: Swertiamarin formulated herbal ointment is an efficient cutaneous ointment for wound healing activity in excision animal models.
Keywords: Swertiamarin, Secoiridoid, Enicostema littorale, wound healing