Research Articles

2019  |  Vol: 5(3)  |  Issue: 3 (May- June)  |  https://doi.org/10.31024/ajpp.2019.5.3.20
Protective role of α-tocopherol on gemcitabine-induced lipid peroxidation

Sarbani Dey Ray

Department of Pharmaceutical Sciences, Assam University, Silchar 788011, India

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Sarbani Dey Ray

Department of Pharmaceutical Sciences, Assam University, Silchar 788011, India

Abstract

Objective: The work was aimed to explore protective role of α-tocopherol on gemcitabine-induced lipid peroxidation. Material and methods: The goat liver tissue homogenate was used a source of lipid. The work was carried out in vitro. Estimation of malondialdehyde and reduced glutathione were considered as marker of lipid peroxidation. They were estimated as per the standard procedure with little modification Results and conclusion: The results showed that gemcitabine has the ability to induce lipid peroxidation to a significant extent by increasing the malondialdehyde content /reducing the reduced glutathione content in the liver tissue homogenate. But α-tocopherol reduces the malondialdehyde content /increase the reduced glutathione content. These indicate the potential of α-tocopherol to suppress the gemcitabine-induced lipid peroxidation.

Keywords: Gemcitabine, α-tocopherol, lipid peroxidation, malondialdehyde, reduced glutathione

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