Research Articles

2020  |  Vol: 6(6)  |  Issue: In Press  |  https://doi.org/10.31024/ajpp.2020.6.6.2
Evaluation of the acute and subchronic toxicity of the aqueous extract of the leaves of Clerodendrum thomsoniae Linn in oral route

Eric Martial Deutchoua Ngounou*, Faustin Dongmo, Yannick Dimitry Mang, Slestin Sokeng Dongmo, Nicolas Njintang Yanou

Department of Biological Sciences, Faculty of Science, University of Ngaoundere, Cameroon

*Address for Corresponding Author

Eric Martial Deutchoua Ngounou

Department of Biological Sciences, Faculty of Science, University of Ngaoundere, Cameroon


Abstract

Objective: Clerodendrum thomsoniae is an important underutilized plant with established lipid-lowering, anti-free radicle, hypoglycemic and antidiabétic effect. The present study was aimed at evaluating the acute and subchronic toxicity in experimental animals. Material and methods: Experiments were conducted according to OCDE425 and OCDE407 guideline for the study of acute and subchronic toxicity. Acute toxicity studies used female and male mices Mus musculus by single dose oral administration of aqueous extract of C. thomsoniae (AECT) at doses of 2000, 5000 and 9000 mg/kg. Subchronic toxicity study was carried out during 28 day daly oral administration of single dose of AECT on albino rats (male and female). The control group received vehicle (10 mL/kg b.m.) and treated groups (II, III and IV) were administrated AECT at the respective doses of 312.5; 625 et 1250 mg/kg. Results: A single dose oral administration of aqueous extract of C. thomsoniae till 9000 mg/kg did not lead to death and changing in the behavior 14 days observation after administration. However, slight change was observed concerning motility 3hours after single oral dose administration more than 6000 mg/kg. daily administration for 28 days of the extract at the therapeutic dose of 1250 mg/kg did not bring any significant changes on the relative mass of organs, transaminases and creatinine. Conclusion: The study showed that with an LD50 greater than 9000 mg/kg and a potential hepatoprotective effect, the aqueous extract of C. thomsoniae leaves is favorable to the production of an improved traditional medicine, after preclinical and clinical tests.

Keywords: Clerodendrum thomsoniae Linn, leaves, acute toxicity, subchronic toxicity

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