Research Articles

2019  |  Vol: 5(3)  |  Issue: 3 (May- June)  |  https://doi.org/10.31024/ajpp.2019.5.3.4
Nature inspired fabrication and evaluation of Silver nanoparticles (AgNPs) from Terminalia catappa extract

Disha M. Dhabarde1*, Mansi Kanchanwar1, Debarshi Kar Mahapatra2, Manish A. Kamble3, Ashwini R. Ingole4

1Department of Pharmaceutical Chemistry, Kamla Nehru College of Pharmacy, Nagpur 441108, Maharashtra, India

2Department of Pharmaceutical Chemistry, Dadasaheb Balpande College of Pharmacy, Nagpur 440037, Maharashtra, India

3Department of Pharmacognosy, Kamla Nehru College of Pharmacy, Nagpur 441108, Maharashtra, India

4Department of Pharmaceutics, Kamla Nehru College of Pharmacy, Nagpur 441108, Maharashtra, India

*Address for correspondence:

Disha M. Dhabarde, PhD

Assistant Professor,

Department of Pharmaceutical Chemistry,

Kamla Nehru College of Pharmacy, Nagpur 441108, Maharashtra, India

Abstract

Objectives: The present research involved the synthesis of AgNPs employing fruit extract of Terminalia catappa (FETC) which will lay the foundation for the environmentally friendly production of nanomaterials. Materials and Methods: The AgNPs were fabricated from silver nitrate and characterized by Ultraviolet-Visible (UV-Vis) spectroscopy and Scanning Electron Microscope (SEM). An anti-bacterial study for the synthesized AgNPs was performed on Staphylococcus aureus (S. aureus). Results: The reduced sample displayed an optical absorption band peak at 259 nm, which was due to absorption attributes of metallic Ag as a result of Surface Plasmon Resonance (SPR). The fruit extract of T. catappa exhibited preparation of AgNPs of range 15-45 nm which were bacilli-like long, somewhat elliptical, and double-stacked morphology. It was noted that a lighter image has been seen primarily at the edges of the particles than the centre, which may be due to the capping of the AgNPs by the capping biomolecules (proteins, alkaloids, etc.). The bactericidal potential screening against S. aureus demonstrated noteworthy activity (ZOI of 25.3±1.14 mm at MIC of 25μg/mL) as compared with the standard drug, ciprofloxacin (33.4±1.03 mm ZOI at MIC of 6.25μg/mL). Conclusion: This study will certainly promote the use of plant extract mediated synthesis of nanomaterials, which will be more eco-friendly, least generation of by-products and exert less toxicity. Thereby, the research opened the avenues for greener fabricating technologies and restricting the use of older chemical technologies which severely affect the environment.

KeywordsTerminalia catappa, silver, nanoparticle, extract, anti-bacterial, synthesis

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