Research Articles

2019  |  Vol: 5(3)  |  Issue: 3 (May- June)  |  https://doi.org/10.31024/ajpp.2019.5.3.21
Rapid and environmentally benign protocol for the synthesis of pyrazolyl-4-thiazolidinone

Mujahed Shaikh*, Devendra Wagare,  Mazahar farooqui, Ayesha Durrani

 Department of Chemistry, Rafiq Zakaria College for Women, Aurangabad (M.S.), India

*Address for Corresponding Author

Mujahed Shaikh

Department of Chemistry, Rafiq Zakaria College for Women, Aurangabad (M.S.), India

Abstract

Objective: The multi-component one-pot approach becomes the need of the research due to its offer advantage like atom economy, minimum reaction time and most important one time workup. Therefore, there is an urgent need to design and developed the efficient and environmentally benign one-pot protocol for the synthesis of pyrazolyl-4-thiazolidinone. Material and Methods: Herein, we have developed a facial and convenient one-pot protocol for the synthesis of pyrazolyl-4-thiazolidinone by irradiating the mixture of isonicotinohydrazide, pyrazolyl carbaldehydes and thioglycolic acid (mercaptoacetic acid) in glycerol at 400 watt under microwave irradiator with 70-75oC temperature. The method provides a better alternative for the existing methods as it involves utilization of in-situ-generated imine linkage, avoids the use of toxic  volatile organic solvents, easy work-up, reduces the reaction time to obtain excellent yield and most important the reaction is completed with reactant hence we have not use any external concerted acid to form the imine linkage. Result: Use of glycerol gives us higher yield, lesser reaction time and the most important it will enhance the reaction due to it forms hydrogen bonding network. The results obtained with excellent yield. Conclusion: This protocol are operationally simple, rapid, 100% atom economy, potential for recycling of the reaction medium, good to excellent yields, no need to separate intermediate precursor and finally agreement with green Chemistry principles, all these aspects make the designed protocol more reliable and attractive and alternative to existing methods.

Keywords:  Pyrazole carbaldehyde, glycerol, thioglycolic acid, green, one-pot

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