Research Articles

2018  |  Vol: 4(6)  |  Issue: 6 (November-December)  |  https://doi.org/10.31024/ajpp.2018.4.6.9
Drug utilization study of anti-diabetics in elderly diabetic, hypertensive in-patients with or without impaired renal function in a tertiary care hospital

Bhandari P.R.1*, Bhandary A.2

1Associate Professor, Department of Pharmacology, SDM College of Medical Sciences & Hospital, Dharwad, Karnataka, India

2Post Graduate, Department of Pharmacology, SDM College of Medical Sciences & Hospital, Dharwad, Karnataka, India

*Address for Corresponding Author

Dr. Prasan R Bhandari

Department of Pharmacology, 

S.D.M.College of Medical Sciences & Hospital, Dharwad, Karnataka, India

Abstract

Background: Hypertension (HTN) and Diabetes mellitus (DM) are the primary contributors to the renovascular mortality and morbidity. Drug utilisation studies (DUS) are prospective tools in the assessment of health care systems. Objectives: To analyse the prescription pattern of anti-microbials in elderly hypertensive diabetic in-patients with or without renal impairment in a tertiary hospital. Methods: The study population comprised of 165 hypertensive diabetic in-patients at Shri Dharmasthala Manjunatheshwara (SDM) Hospital. Questionnaire based evaluation was carried out and prescriptions of patient with HTN and DM at and above the age of 60 years irrespective of gender were included. Results: Out of 226 anti-diabetic drugs, 193 were single drugs and 33 were FDCs, among the total 123 drugs were used in patients with impaired renal function. There was no significant difference in the number of anti-diabetic drugs used in patients with impaired renal function and in patients with normal renal function, (p >0.05). Out of 193 single drugs, 83.42% (n=161) were insulins and 16.58% (n=32) were of oral anti-diabetic drugs. Among insulins, intermediate acting insulins were used in majority 63.73% (n=123) followed by long acting insulins, 19.69% (n=38). Amongst oral antidiabetics drugs, biguanides, with metformin being the most commonly prescribed drug, 9.84% (n=19). Conclusions: Intermediate acting insulin was the most common class of drug prescribed and combination of glimepiride + metformin was the most common FDC prescribed in patients with or without impaired renal function.

Keywords: Antidiabetic, biguanides, renal impairment, metformin

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