Research Articles

2019  |  Vol: 5(6)  |  Issue: 6 (November-December)  |  https://doi.org/10.31024/ajpp.2019.5.6.12
Protective effect of extracts of Cocos nucifera endocarp on Paracetamol induced hepatotoxicity in rats

Nishant Singh Katiyar*, Rajesh Asija

Maharishi Arvind Institute of Pharmacy, Jaipur, Rajasthan- 302020, India

*Address for Corresponding author

Nishant Singh Katiyar

Maharishi Arvind Institute of Pharmacy, Jaipur, Rajasthan- 302020, India

Abstract

Background: Hepatotoxicity related to many drugs or their transformation to chemically reactive metabolites that may be influenced by therapeutic, physiological or nutritional factors interfering with drug elimination or formation of a reactive metabolite or their detoxification.  It is caused by drug accumulation or may be due to metabolic inhibition by other drugs or liver damage. Objective: Cocos nucifera (Arecaceae) have variety of ethnic medicinal uses along with antioxidant activity. Objective of present study was to evaluate the hepatoprotective activity with alcoholic (AEECN) and aqueous (AQEECN) extracts of endocarp of Cocos nuciferaMaterials and methodsCocos nucifera fruit endocarp collected from local market of Kanpur were authenticated by NISCAIR, New Delhi and dried in shade at room temperature then subjected to size reduction to a fine powder with the help of mixer grinder. Paracetamol and Silymarin are gift samples from Pharmed, Bangalore, India and Micro Labs- Bangalore respectively. Thiopental sodium was purchased from Neon Laboratories Ltd., Mumbai, India. The following biochemical kits SGPT, SGOT, ALP, BILT and BILD were purchased from Erba Diagnostics Mannheim GmbH, Germany. Results: In LD50 studies for AEECN and AQEECN up to the maximum dose level of 2000 mg/kg dose no mortality was observed in any of the animals, indicating the practically nontoxic. When compared to toxicant control groups both the extracts have significantly reduced the paracetamol induced elevated levels of serum ALT, AST, ALP, BILT and BILD. The histopathological changes (steatosis), necrosis etc. were partly or fully prevented in animals treated with the two extracts. Conclusion: AEECN and AQEECN showed a significant hepatoprotective effect against paracetamol induced hepatic damage. The medium and high doses of AEECN and AQEECN (200 and 400 mg/kg) treated groups showed better hepatoprotective activity when compared to standard drug silymarin (25 mg/kg p.o.) treated group.

Keywords: Cocos nucifera, endocarp extracts, paracetamol, silymarin, hepatoprotective activity

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