Research Articles

2019  |  Vol: 5(4)  |  Issue: 4 (July- August)  |  https://doi.org/10.31024/ajpp.2019.5.4.6
Influence of preparation methods of folic acid-β cyclodextrin complexes on its photostability

Vikas Yadav1, Vikas Budhwar1*, Manjusha Choudhary2                  

1Department of Pharmaceutical Sciences, Maharishi Dayanand University Rohtak-124001

2University Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra-136118

*Address for Corresponding Author:

Dr. Vikaas Budhwar

Assistant Professor,

Department of Pharmaceutical Sciences,

Maharishi Dayanand University, Rohtak-124001, Haryana, India

Abstract

Objective: The present research aims toward studying the influence of method of preparation of folic acid-β cyclodextrin complexes in increasing its photostability, which is susceptible to degrade in the presence of light. Materials and methods: Folic acid-β cyclodextrin complexes were prepared by solvent evaporation, co-precipitation and kneading method and characterized by FT-IR, DSC and XRD. These complexes and the pure drug were simultaneously subjected to accelerated photostability studies according to Q1B ICH 1996 guidelines. The samples were withdrawn in duplicate everyday for seven days and were analyzed for the quantitative estimation of folic acid by UV visible spectrophotometer method and the results were compiled. Result and conclusion: After the seventh day the percentage drug degraded in the complexes was (48.05%, 58.05%, and 61.96%) by solvent evaporation, co-precipitation and kneading method respectively. In the end of seventh day pure drug degraded to 78.05%. The photo degradation follows first order kinetics.

KeywordsFolic acid, photo degradation, kinetics, photostability, cyclodextrin complexes, derivatization

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