Divya Singh1*, Jai Singh Vaghela1, Pushpendra K. Saini2, Narendra Sharma2
1Bhupal Nobles College of Pharmacy, Udaipur, Rajasthan, India
2Sri Balaji College of Pharmacy, Benad Road, Jaipur, Rajasthan, India
*Address for Corresponding Author
Bhupal Nobles College of Pharmacy, Udaipur, Rajasthan, India
Objective: Comparative Anti-arthritic Activity of seed extract of Pongamia pinnata (L.) Pierre and Bryophyllum pinnata leaves by in vitro model. Materials and methods: Pongamia pinnata (L.) Pierre (Family: Leguminoseae) and Bryophyllum pinnata (Family: Crassulaceae) are a medicinal plant which is indicated for the treatment of arthritis in folklore medicine. The anti-arthritic activity of Pongamia pinnata seed and Bryophyllum pinnata leaves ethanolic extract were done by Inhibition of protein denaturation in vitro methods. The ethanolic extract of Pongamia pinnata seeds and Bryophyllum pinnata leaves were subjected to in vitro Inhibition of protein denaturation in various concentrations i.e. 50, 100, 200, 400, 800, 1000 and 2000μg/ml. Results: P. pinnata and B. pinnata both extracts exhibited a concentration dependent inhibition of protein (albumin) denaturation. The prepared extracts showed better anti-Arthritic activity than the standard drug; when compared with each other, P. pinnata extracts showed better anti- arthritic activity compared to B. pinnata extracts. Conclusion: In the present study, Pongamia pinnata seed extract showed better activity comparative to Bryophyllum pinnata leaves and standard drug.
Keywords: Pongamia pinnata, Bryophyllum pinnta, anti-arthritic activity