Kundu Smita S., Digvijaysinh G. Rana∗
Department of Pharmacology, Babaria Institute of Pharmacy, Vadodara, Gujarat, India
*Address for Corresponding Author
Digvijaysinh G. Rana
Department of Pharmacology,
Babaria Institute of Pharmacy, Vadodara, Gujarat - 391240, India
Background: It has been reported that there is an abnormal prostaglandin E levels in depression. Various studies indicated that there has been an elevated levels of prostaglandins (PGs) specifically prostaglandin E2 (PGE2) in depression. Objective: The objective of the present study was to evaluate the influence of Loxoprofen on immobility time in absence or presence of Lipopolysaccharide in tail suspension test model of depression in mice. Material and Methods: There was a measurement of immobility time in tail suspension test (TST) in which mice were subjected to the treatment of Loxoprofen (16.8 mg/kg, p.o.). The same drug treatment was given 60 min before Lipopolysaccharide [LPS](0.5 mg/kg, i.p.) and 23 h following LPS separately in mice. There was an evaluation of effect of above mentioned drugs in locomotor activity of mice. Results: The result of the present study indicated that mice treated with Loxoprofen showed a significant decrease in the immobility time in tail suspension test. LPS-treated mice presented an increase in immobility time when compared to controls 24 h after LPS administration. Similarly, Loxoprofen could only reverse but did not prevent the LPS-induced alterations in the TST. There was no significant effect of Loxoprofen on locomotor activity in mice. Conclusion: The results of the present study indicated that Loxoprofen could influence LPS induced alterations in immobility time in mice in tail suspension test. It also indicated possible anti-depressant effect of Loxoprofen in mice subjected to tail suspension test model of depression, having its possible implication in future treatment of depression.
Keywords: Depression, tail suspension test, lipopolysaccharide, Loxoprofen