Natarajan P.*, Jasmine Grace
Sankaralinagam Bhuvaneswari College of Pharmacy, Sivakasi, Tamil Nadu, India
*Address for Corresponding Author
Associate Professor & Head
Department of Pharmacology
Sankaralingam Bhuvaneswari college of Pharmacy, 3/77-C, Anaikuttam Road, Anaikuttam-626130, Sivakasi- Tamil Nadu, India
Objective: The present study aimed to cardioprotective activity of hydroalcoholic extract of Foeniculum vulgare Mill. (HEFV) fruits on isoproterenol induced myocardial infarction in albino rats. Materials and Methods: Fruits of Foeniculum vulgare Mill. were air dried, coarsely powered and extracted with a mixture of alcohol and water (50:50, v/v) by a round bottom flask. The solvent was removed and dried crude extract was used for investigation. The animals were divided into 5 groups, Group I : Normal control (normal saline 10ml/kg p.o. for 30 days). Group II: Control (10ml/kg p.o. of normal saline for 28 days +Isoproterenol (ISO)-85mg/kg, s.c. on 29th and 30th day only).Group III: Hydroalcoholic extract of Foeniculum vulgare Mill-200mg/kg, p.o. for 30 days and ISO-85mg/kg, s.c. on 29th and 30th days only). Group IV: Hydroalcoholic extract of Foeniculum vulgare Mill-250mg/kg, p.o. for 30 days + ISO-85mg/kg, s.c. on 29th and 30th days only. Group V: Hydroalcoholic extract of Foeniculum vulgare Mill-400mg/kg, p.o. for 30 days + ISO-85mg/kg, s.c. on 29th and 30th days only). Results: The Hydroalcoholic extract of Foeniculum vulgare Millfruits at the dose of 200, 250 and 400mg/kg/p.o. respectively produce significant salvages the heart. Conclusion: In the current study, we found that HEFV protected myocardium from isoproterenol induced myocardial infarction and structural injury via normal levels of diagnostic marker enzymes and by restoring the glutathione and lipid peroxidation levels.
Keywords: Myocardial infarction, Foeniculum vulgare Mill, Isoproterenol, lipid peroxidation, glutathione