Research Articles

2019  |  Vol: 5(3)  |  Issue: 3 (May- June)  |  https://doi.org/10.31024/ajpp.2019.5.3.12
Synthesis, characterisation and biological evaluation of 1, 4 disubstituted 1, 2, 3 triazoles

Anis Ahmed Shaikh, Mohamad Asif, Prashant Netankar, Sayyad Sultan Kasim*

Post Graduate and Research Centre , Maulana Azad College, Aurangabad 431001 Maharashtra, India

*Address for Corresponding Author

Sayyad Sultan Kasim

Post Graduate and Research Centre, Maulana Azad College, Aurangabad 431001 Maharashtra, India

Abstract

Objective: The main objective of this research work was to synthesis the triazoles compounds by Click reaction and evaluated their antibacterial activities against gram positive and gram negative bacteria. Material and Methods: In this work 1,4-disubstituted 1,2,3-triazole  compounds (3a-3i) were  synthesized by Azide Alkyne Cycloaddition reaction  and characterized by IR,1H NMR and Mass spectroscopy. Further these compounds were evaluated for antibacterial activity against Bacillus substilusStaphylococcus aureus and Escherichia coli by using Ciprofloxacin as standard compound with various concentrations. Results: Among all the compounds (3a-3i) which were screened for antibacterial activity, the compounds 3c, 3d, 3e and 3i were found to be excellent antibacterial agents. Conclusion: The presence of electron donating, electron withdrawing and halogen groups plays an important role of biological activity of compounds.

Keywords: Alkyne, antibacterial activity, azide, click reaction, triazole

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