Research Articles

2019  |  Vol: 5(5)  |  Issue: 5(September- October)  |  https://doi.org/10.31024/ajpp.2019.5.5.5
Effect of Tamarindus indica extracts on haematological parameters in albino rats infected with Entamoeba histolytica parasite

Mansour Abdulnabi H. Mehdia*, Fadel Y. S. Alarabia, Gozif Mohammed N. Omarb, Vidya Pradhana*

aDepartment of Zoology, Dr. Rafiq Zakaria College for Women, Aurangabad, 431001 India.

bDepartment of Biochemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, 431001, India.

*Address for Corresponding Author

Mansour Abdulnabi H. Mehdi

Department of Zoology, Dr. Rafiq Zakaria College for Women, Aurangabad, 431001 India.

Abstract

Objective: The study aimed to investigate the effect of Tamarindus indica extracts on hematological parameters in rats infected with Entamoeba histolytica parasite which causes Amoebic dysentery disease. Material and Methods: A total of 12 albino rats were grouped into 4 groups of 3 rats each. Group 1 of rats serve as negative control group, while group 2, 3 and 4 were treated with metronidazole drug, ethanolic extract and aqueous extract respectively, at concentration 500mg/kg for 10 days, the blood parameters were evaluated  hemoglobin (HG), hematocrit (HCT), red blood cell count (RBC), mean platelet volume (MPV), mean cell volume (MCV), mean corpuscular haemoglobin (MCH), red cell distribution width (RDW), procalcitonin test (PCT), total white blood cell platelet distribution width (PDW), mean corpuscular haemoglobin concentration (MCHC), total white blood cell (TWBC), lymphocyte (LY), monocyte (MO) and mixed cells of neutrophile, eosinophile and basophile in the rats blood, using haematology auto-analyser system (CBC Mindray BC-3000Plus). Results: Show a significant increase at P≤0.05 in HG, HCT, RBC, MPV, MCV, MCH, RDW, PCT, TWBC, LY and mixed cells of neutrophile, eosinophile and basophile when compare with metronidazole drug and the control group of rats during treatment stages. The results also indicate a significant decrease at P≤0.05 in PDW, MCHC and MO compared to the control group of rats. Conclusion: Based on the results of this study, the present data suggest that the efficiency of T. indica extracts in improving blood standards through variations occurring in blood proportion.

Keywords: Tamarindus indica,  Entamoeba histolytica, Haematological parameters, Albino rats

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