Research Articles

2021  |  Vol: 7(6)  |  Issue: 6 (November-December)  |  https://doi.org/10.31024/ajpp.2021.7.6.2
Effect of aqueous extract of the Clerodendrum thomsoniae Linn. leaves on the onset of hyperlipidaemia in vivo and the inhibition of gain mass on wistar rats

Deutchoua Ngounou Eric Martial1*, Mang Yannick Dimitri2, Dongmo Faustin1, Youdom Patrick3, Sokeng Dongmo Sélestin1, Njintang Yanou Nicolas3

1Department of Biological Sciences, Faculty of Science, University of Ngaoundere, PO Box 454, Ngaoundere-Cameroon

2Department of Tourism and Hotel Management, Higher Technical Teachers Training College, University of Yaound L, Po Box 886, Ebolowa-Cameroo

3Department of Food Science and Nutrition, Physical and Chemistry Food Laboratory, Ensai, University of Ngaoundere, Po Box 455, Ngaoundere-Cameroon

*Address for Corresponding author

Deutchoua Ngounou Eric Martial

Department of Biological Sciences, Faculty of Science, University of Ngaoundere, PO Box 454, Ngaoundere, Cameroon

Abs​tract

Background: The genus of clerodendrum is among the most important in the plants’ kingdom with many species known for their medicinal properties and among which Clerodendrum thomsoniae is well represented. Previous studies established hypolipidemic, antioxidant and antidiabetic activities obtained from aqueous extract (AECT) of Clerodendrum thomsoniae. Objective: This study aims at evaluating the effect of the AECT on the onset of hyperlipidaemia in wistar rats. Material and methods: The antihyperlipidaemia effect of administrated AECT (312,5, 625 and 1250 mg/kg, p.o.) followed by the HFD in rats was investigated for five weeks. Lipid parameters such as total cholesterol (TC), Low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and triglycerides (TG) levels were measured in serum. The modifications in the body mass, feed intake have been observed and evaluated. Administration of distilled water followed by HFD induced an alteration in serum, lipid profile (triglyceride, cholesterol, HDL, and LDL) in negative control rats. Results and conclusion: Meanwhile in rats subjected to AECT (312.5, 625 and 1250 mg/Kg p.o) no significant changes were noticed with the normal control rats (p < 0.05). On the other hand, concerning body mass, no significant changes (p < 0.05).  were observed in between the normal control rats and rats receiving AECT followed by HFD for five weeks. AECT showed the ability to prevent the onset of hyperlipidaemia in rats. Hence, it could be important in the management of cardiovascular diseases, obesity and metabolic syndromes.

Keywords: Clerodendrum thomsoniae, High fat diet, antihyperlipidaemia, Cholesterol, hyperlipidaemia, antidiabetic

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