Research Articles

2018  |  Vol: 4(4)  |  Issue: 4 (July- August)  |  https://doi.org/10.31024/ajpp.2018.4.4.8

One pot multicomponent synthesis and biological screening of novel chloroacetyl amino benzothiazoles

Anil B. Chidrawar*

P.G. Department of Chemistry, A. V. Education Society’s, Degloor College, Degloor, Dist. Nanded, Maharashtra, India.

*Address for Corresponding Author

Anil B. Chidrawar

P.G. Department of Chemistry, A. V. Education Society’s, Degloor College, Degloor, Dist. Nanded, Maharashtra, India                         

Abstract

Objective: A Literature survey shows that benzothiazole and its derivatives possess different microbial activities, which of most potent activity is anti-bacterial activity. The objectives of the present work are to synthesize certain benzothiazole derivatives and study their antibacterial activity in particular. Materials and methods: A mixture of 4-substituted aniline, potassium thiocyanate and bromine 5⁰C in glacial acetic acid which on reflux with chloroacetyl chloride in benzene at 70⁰C yields 2-chloroacetyl amino-6-substituted benzothiazole. The synthesized compounds were characterized by elemental analysis and spectral data. Results and conclusion: As expected substituted benzothiazoles exhibited antimicrobial activity. 2-chloroacetyl amino-6-substituted benzothiazole moieties independently showed a broad spectrum of antibacterial activity against Gram positive and Gram negative bacteria.

Keywords: 4-substituted aniline, potassium thiocyanate, glacial acetic acid, chloroacetyl chloride