Research Articles

2020  |  Vol: 6(1)  |  Issue: 1 (January-February)  |  https://doi.org/10.31024/ajpp.2020.6.1.5
Evaluation of altered ground matrix and matrix metalloproeinase (MMP’S) in wound healing with Aloe vera extract

Mohammed Ziauddin Sarkhil1, Prakash K. G.2, Abdul Haseeb1, Khalid Ahmed3, Padmanabha Udupa4, Honnegowda Thittamaranahalli Muguregowda5*

1Department of Pharmacology, Kannur Medical College, Kannur, Kerala, India.

2Department of Anatomy, Azeezia Institute of Medical sciences, Kollam, Kerala, India

3Department of Microbiology, KMCT Medical College, Calicut, Kerala, India.

4Department of Biochemistry, Kasturba Medical College, Manipal, India.

5Department of Anatomy, Kannur Medical College, Kannur, Kerala, India

*Address for Corresponding Author

Honnegowda Thittamaranahalli Muguregowda

Department of Anatomy, Kannur Medical College, Kannur, Kerala, India

 

Abstract

Background:  Aloe vera is known for its anti-tumor, anti-inflammatory, skin protection, anti-diabetic, anti-bacterial, anti-viral, antiseptic, and wound healing properties. This study was undertaken to evaluate the wound healing properties of Aloe vera (Aloe barbadensis) on cutaneous wound healing in dead space wounds created in rats. Materials and methods: Thirty rats were randomly divided into two equal groups (control and experimental). Wound created surgically were treated with Aloe vera aqueous extract through orally. Results: Increases in the level of hydroxyproline cross linking and collagen maturation enzyme lysyl oxidase were observed indicating definite prohealing action. In addition significant increase in the levelof antioxidants such as catalase, glutathione peroxidase and decrease in oxidative biomarker Malondialdhyde (MDA) and matrix destryoing enzyme MMP-2 and 9 were noted in the Aloe vera treated group. Conclusion: Aqueous extract of Aloe vera promotes wound healing by wound contraction and accelerates healing significantlyby increase in collagen and antioxidants enzymes.

Keywords:  Wound healing, hydroxyproline, antioxidant enzymes, Aloe vera

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