Sandeep Doppalapudi*, Vidyadhara Suryadevara, Siva Krishna Ainampudi, Sasidhar Lankapalli Reddyvallam, Ramu Anne
Chebrolu Hanumaiah Institute of Pharmaceutical Sciences, Chandramoulipuram, Chowdavaram, Guntur, Andhra Pradesh – 522019, India
*Address for Correspondence:
Doppalapudi Sandeep,
Assistant Professor,
Chebrolu Hanumaiah Institute of Pharmaceutical Sciences, Chandramoulipuram, Chowdavaram,
Guntur, Andhra Pradesh, India – 522019.
Abstract
Objective: The main objective of the present research is to formulate lemon grass oil liniment and evaluate its anti-inflammatory activity on Wistar rats. Materials and methods: Lemon grass oil liniment and turpentine oil liniments were formulated using tween 80 as surfactant in different ratios. After evaluation of various physical parameters like globule size, pH, viscosity, the optimized formulations namely LL5 and TL5 were selected for pharmacological evaluation. These formulations were subjected for evaluation of anti-inflammatory effect using carrageenan induced paw edema method. Results: The edema in paw was measured using plythesmometer. LL5 reduced 63.15% of oedema which was induced by carrageenan on sub-plantar administration when compared with untreated control groups, whereas TL5 reduced 56.84% of oedema. A significant increase in the percentage inhibition of heat induced haemolysis and protein denaturation were observed with LL5 when compared to that of the standard group which clearly indicates the anti-inflammatory activity of lemon grass oil. Conclusion: Thus from the present study, it was concluded that the lemon grass oil liniment made with 10% of tween 80 shows significant anti-inflammatory activity.
Keywords: Lemon grass oil, Turpentine oil, liniment, anti-inflammatory
