Pitchika Subrahmanyam1, Bhairy Srinivas2, Shaik Harun Rasheed3, Kondapuram Parameshwar3*
1Department of Pharmaceutics, GITAM School of Pharmacy, GITAM (Deemed to be University), Visakhapatnam 530 045, Andhra Pradesh, India.
2Department of CDE, Osmania University, Hyderabad 500 007, Telangana, India
3Department of Pharmaceutics, School of pharmacy, Gurunanak Institutions Technical Campus (GNITC), Hyderabad 501 506, Telangana, India.
*Address for Corresponding author
Kondapuram Parameshwar
Department of Pharmaceutics,
School of pharmacy, Gurunanak Institutions Technical Campus (GNITC), Hyderabad 501 506, Telangana, India
Abstract
Graphene, a two-dimensional substance with distinctive mechanical, optical, and electrical characteristics, has recently attracted considerable attention. Researchers have explored the use of graphene-based nanomaterials in various biomedical contexts, such as drug delivery, biosensing, tissue engineering, and cancer treatment. These materials hold significant promise for advanced therapeutic purposes, including precise cancer cell targeting through ligand functionalization and heat generation for photothermal therapy to eradicate cancer cells. Nevertheless, there are noteworthy challenges to overcome, with a primary concern being the potential toxicity of graphene-based substances due to uncertainties regarding their long-term effects on human health. Thus, it is imperative to rigorously assess the safety of these materials before their adoption in clinical applications. This review article consists of overviews of recent advancements in graphene-based nanomaterials for advanced therapeutics and discusses the associated obstacles. By comprehending both the potential benefits and limitations of graphene-based materials, we can continue to push the boundaries of biomedical research and potentially transform the field of therapeutics.
Keywords: Graphene-based nanomaterials, targeted therapy, photothermal therapy, biocompatibility, safety, clinical applications
