Research Articles

2018  |  Vol: 4(1)  |  Issue: 1(January-February)  |  https://doi.org/10.31024/ajpp.2018.4.1.8

Determination of Rosuvastatin Calcium in bulk and Pharmaceutical dosage forms by using UV-Spectrophotometric method

Harjeet Singh¹*, Ram Dayal Gupta², Girendra Gautam³

¹Department of pharmacy, Bhagwant University, Ajmer 305004, Rajasthan, India

²Department of Pharmaceutics, H.R. Institute of Pharmacy, Morta, Ghaziabad 201003, Uttar Pradesh, India

³Department of pharmacy, Bhagwant University, Ajmer 305004, Rajasthan, India

*Corresponding Author

Harjeet Singh

Department of Pharmacy, Bhagwant University, Ajmer

Rajasthan-305004

Abstract

Objective: The aim of the present work was to develop a simple and sensitive UV spectrophotometric method for the estimation of rosuvastatin calcium in bulk and in pharmaceutical dosage form. Material and methods: Rosuvastatin calcium exhibits maximum absorbance at 244 nm with apparent molar absorptivity of 7.1862 × 10⁴ L/mol.cm in methanol as solvent. Beer’s law was found to be obeyed in the concentration range 2-18 µg /ml for rosuvastatin calcium. Result and discussion: The results of the study demonstrated that the developed procedure was accurate, precise and economical. This method is further extended to pharmaceutical dosage form. Conclusion: In this method, no interference from any pharmaceutical additives and diluents were found. The validation of the analysis was done by statistically and recovery studies.

Keywords: Rosuvastatin calcium, UV spectrophotometric method, Validation