Research Articles

2022  |  Vol: 8(4)  |  Issue: 4 (July- August)  |  https://doi.org/10.31024/ajpp.2022.8.4.1
Transmembrane passage of Sulfamethoxazole/Trimethoprim in combination with leaves extracts of Pseudocedrela kotschyi and Crossopteryx febrifuga

Thierry Lenoir Ayoman Djadji*, Eric Joseph Balayssac, Armelle Sandrine Aka-Any Grah, Nounaferitien Awa Silue, Gbongue Eric Tia, Sylvain Landry Kouakou, Gisèle N'doua Kouakou-Siransy

Pharmaceutical and Biological Sciences, Felix Houphouet Boigny University, 01 BPV34 Abidjan

*Address for Corresponding Author

Thierry Lenoir Ayoman Djadji

Pharmaceutical and Biological Sciences, Felix Houphouet Boigny University, 01 BPV34 Abidjan

 

Abstract

Background : The use of herbal medicines in combination is common throughout the world and particularly in Africa. It can be the cause of many adverse effects that can lead to death. Objective : The aim of this study is to evaluate the absorption of the transmembrane passage of Crossopteryx febrifuga and Pseudocedrela kotschyi in association with Sulfamethoxazole. Material and Methods: We used the Ussing Chamber (TBC-Biomécatronics SAS, France) and HPLC DAD methods to analyse transepithelial passage of Crossopteryx febrifuga and Pseudocedrela kotschyi in association with Sulfamethoxazole in order to evaluate the herbal and drugs pharmacokinetic absorption. Results : Combination of the aqueous extract Pseudocedrela kotschyi with Sulfamethoxazole in the donor chamber of the Ussing Chamber causes an increase in Sulfamethoxazole concentrations in the recipient chamber (p<0.0001). This concentration is 5 to 8 times higher than the concentration of Sulfamethoxazole alone. The association Sulfamethoxazole + the aqueous extract Crossopteryx febrifuga causes a decrease in Sulfamethoxazole concentrations. This decrease is observed from the 30th minute to the 120th minute compared to Sulfamethoxazole alone. Conclusion : There are interaction pharmacokinetic between Crossopteryx febrifuga and Pseudocedrela kotschyi in association with Sulfamethoxazole. These plants should be used with caution in association with Sulfamethoxazole.

Keywords: Ussing Chamber, Drugs-Herbal interactions, Pharmacokinetic, Crossopteryx febrifuga, Pseudocedrela,  kotschyi, Sulfamethoxazole/ Trimethoprim

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