Kouakou S. Landry1, Yao-Kouassi Philomène Akoua2,3, Koffi Kouamé Jean-Michel2, Kimou Anderson Claver2, Kouakou-Siransy Gisèle2
1Laboratoire de Pharmacologie, UFR Sciences Pharmaceutiques, Université FHB, 01 BP V34 Abidjan, Côte d’Ivoire
2Laboratoire de Constitution et Réaction de la Matière, UFR Sciences des Structures de la Matière et de Technologie, Université Félix Houphouët-Boigny, 22 BP 582 Abidjan, Côte d’Ivoire.
3Université de San Pedro, BP V1800 San Pedro, Côte d’Ivoire
*Address for Corresponding Author
Kouakou S. Landry
Laboratoire de Pharmacologie, UFR Sciences Pharmaceutiques, Université FHB, 01 BP V34 Abidjan, Côte d’Ivoire
Abstract
Objectives: S. afzelii aqueous leaves extract is used in traditional Ivorian medicine to fight against gastric disorders, colic, dysentery and kidney problems. This study aimed was to compare decoction and methanolic phytochemical composition of S. afzelii extracts from aerial parts and evaluate anti-inflammatory potential of this plant, in order to bring out solid scientific argument which can justify its use in many pathologies. Methods: Phytochemical screening of aqueous decoction and hydro methanolic extracts obtained from leaves of S. afzelii was evaluated with standard methods. Aqueous decoction was submitted first in rat's paw irritation test induced by formalin and secondary rat's paw oedema induced by carrageenan test was performed to appreciate anti-inflammatory activity. Results: Qualitative phytochemical screening showed presence of tannins, saponins, flavonoids, sterols, terpenoids and coumarins in both extracts. All doses evaluated in formalin test (25-50-100 and 200 b.wt.) have reduced significantly production of chemical inflammation mediators respectively up to 59.09%; 54.22%; 54.10% and 62.88% with an effect comparable to ketoprofen which was 55.56%. Concerning carrageenan-induced oedema test, strong limited oedema evolution was observed at 10 b.wt., with 60.28%, 66.92%, 61.30% and 45.29% respectively at 1st, 2nd, 3rd and 4th hours. However, these effects are not superior to ketoprofen, which decrease during 4 hours up 71.35, 73.69, 68.87 and 57.06%. Conclusion: Aqueous leaves and hydro methanolic extracts of S. afzelii revealed presence of flavonoids, saponins, sterols, terpenoids, tannins and coumarins. Aqueous leaves of S. afzelii possessed good anti-inflammatory potential.
Keywords: Secamone afzelii, phytochemical screening, inflammation, formalin, carrageenan