Abstract

Objective: The present study was designed to investigate the anti-epileptic activity of hydroalcohol extract of Mentha cordifolia against Pentylenetetrazole (PTZ) induced epilepsy in Swiss albino mice. Materials and Methods: The hydroalcohol extract of Mentha cordifolia was screened for its antiepileptic activity against Pentylenetetrazole (PTZ) induced epilepsy. The extract was given orally at the doses of 200 mg/kg and 400 mg/kg for 15 consecutive days prior to the induction of seizure. The protection action against PTZ induced seizure was evaluated by behavioral paradigm. Results: In Pentylenetetrazole induced epilepsy model, hydroalcohol extract of Mentha cordifolia at 200 mg/kg and 400 mg/kg treated groups showed significant increase in onset of action and decrease in death latency, number of convulsions, number of Straub’s tail, duration of convulsions, jerking, tonic, clonic, duration of Stuper and Straub’s tail was observed. Conclusion: Present study shows that the potent antiepileptic role of hydroalcohol extract of Mentha cordifolia on Swiss albino mice showed significant changes in behavioral paradigm. Further studies are required to elucidation the potent action of Mentha cordifolia on treatment of epilepsy.

Keyword: Mentha cordifolia, pentylenetetrazole, antiepileptic, convulsions, seizures