Research Articles

2022  |  Vol: 8(1)  |  Issue: 1(January-February)  |  https://doi.org/10.31024/ajpp.2022.8.1.1
Anti-oxidant and anti-inflammatory effects of Urtica dioica against cerebral ischemia-reperfusion injury in rats

R. Padmavathi1*, Akula Annapurna2

1G. Pulla Reddy College of Pharmacy, Hyderabad, India

2AU College of Pharmaceutical Sciences, Andhra University, Vishakhapatnam, India

*Address for Corresponding Author

Dr. R. Padmavathi,

Associate Professor,

Department of Pharmacology,

G. Pulla Reddy College of Pharmacy, Hyderabad – 500028, Telangana, India.

 

Abstract

Objective: In our previous study, Urtica dioica (UD) was found to protect against cerebral ischemia reperfusion injury (CIRI) in a rat model of bicommon carotid artery occlusion (BCCAO). The mechanisms behind the protective effects of UD on BCCAO-induced rats, however, are still unknown. Using BCCAO rats, the goal of this study was to see if UD reduced BCCAO-induced CIRI through anti-oxidant and anti-inflammatory pathways. Material and Methods: The following parameters were measured: (1) percentage (%) area of brain infarction; (2) Brain levels of antioxidant enzymes (3) Brain levels of inflammatory cytokines, including tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-β). Results: BCCAO considerably raised the percent area of brain infarction, whereas UD administration significantly reduced the percent area of brain infarction in these animals.  With BCCAO, there was a considerable increase in brain TNF- and IL- levels, which was significantly reduced by UD. Furthermore, BCCAO reduced anti-oxidant enzymes significantly. UD, on the other hand, significantly reduced the activity of anti-oxidant enzymes. Conclusion: The data suggests that, inhibition of oxidative stress and inflammatory mediator release may be involved in the protective benefits of UD in BCCAO model rats.

Keywords: Cerebral ischemia, reperfusion injury, Urtica dioica, inflammatory markers

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